HORDB

ID: hor005223
Uniprot ID: P01265
Protein name: Calcitonin-3
Gene name: NA
Organism: Oncorhynchus kisutch (Coho salmon) (Salmo kisutch)
Family: Calcitonin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Mechanism: Calcitonin 1 is less active than calcitonins 1 or 2. Only this species of salmon possesses calcitonin 3.
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P01265-F1.pdb

hor005223_AF2.pdb

hor005223_ESM.pdb

Mass:	397208	Formula:	C145H241N43O46S3
Absent amino acids:	EIWY	Common amino acids:	L
pI:	8.82	Basic residues:	4
Polar residues:	14	Hydrophobic residues:	8
Hydrophobicity:	-24.69	Boman Index:	-4308
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	73.13
Instability Index:	4242.19	Extinction Coefficient cystines:	125
Absorbance 280nm:	4.03